CD140 antigen-like family member B ; Beta-type platelet-derived growth factor receptor ; CD140 antigen-like family member B ; Platelet-derived growth factor receptor 1 ; PDGFR-1 ; CD140b ; PDGFR ; PDGFR1
Categories
Elisa
Function
Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.
Specificity
Natural and recombinant Dog Beta-type platelet-derived growth factor receptor
Homodimer, and heterodimer with PDGFRA. Interacts with APS. The autophosphorylated form interacts directly with SHB and with PIK3C2B, maybe indirectly. Interacts with GRB7 and GRB10.