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Home / Assay Kits / ELISA Kits

ELISA Kit for Dog Aprataxin

SKU : BHE13800821

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9623d
Alternative Names	Forkhead-associated domain histidine triad-like protein ; FHA-HIT
Categories	Elisa
Function	DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.
Specificity	Natural and recombinant Dog Aprataxin
Subcellular Location	Nucleus nucleoplasm Nucleus nucleolus Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization.
Entryname	APTX_CANFA
Protein Name	Aprataxin
Sequence	50: MMRMCWLVRQ ; DNQHQRIKLP ; HLEAVMVGRG ; PETKIIDKKC ; SRQQVQLKAE ; 100: CNKGYVKVKQ ; VGVNPTSIDS ; VIIGKDQEAK ; LQPGQVLHMV ; NELYPYIVEF ; 150: EEEAESPGLE ; THRKRKRSGN ; SDSIERDAAQ ; EAESSTGLEP ; GSDSSQCSVP ; 200: LNKGKDAPTK ; KESLGHWSQG ; LKISMQDPKM ; QVYKDEQVVV ; IKDKYPKARY ; 250: HWLVLPWASV ; SSLKAVTGEH ; LELLKHMHTV ; GEKMIADFAG ; SSKLRFRLGY ; 300: HAIPSMSHVH ; LHVISQDFDS ; PCLKNKKHWN ; SFNTEYFLES ; QAVIEMVQHA ; 342: GRVSVRDGMP ; ELLKLPLRCH ; ECQQLLPSIP ; QLKEHLRRHW ; PK
Sequence Length	342
String	P61797
Sub Unit	Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT and p53/TP53. Interacts with NCL. Interacts (via FHA-like domain) with MDC1 (phosphorylated).

Uniprot	P61797
Gene Name	APTX
Immunogen Species	Canis Lupus Familiaris (Dog)
Kegg	cfa:442943
Unigene	Cfa.113

Reference	1. "Identification of human FHA-HIT gene homolog in dog." Chen Y., Huang C.-H. Submitted (2002-12) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800821	E9623d	96T	$900		Add to Cart

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