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Home / Assay Kits / ELISA Kits

ELISA Kit for Chicken Tyrosine-protein kinase BTK

SKU : BHE13802045

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1915c
Alternative Names	Bruton tyrosine kinase
Categories	Elisa
Function	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
Specificity	Natural and recombinant Chicken Tyrosine-protein kinase BTK
Subcellular Location	Cytoplasm Cell membrane Peripheral membrane protein Nucleus In steady state, BTK is predominantly cytosolic (By similarity). Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain (By similarity). Plasma membrane localization is a critical step in the activation of BTK (By similarity). A fraction of BTK also shuttles between the nucleus and the cytoplasm.
Entryname	BTK_CHICK
Platform	PF00779
Protein Name	Tyrosine-protein kinase BTK
Sequence	50: MASIILESIF ; LKRSQQKKKT ; SPLNFKKRLF ; LLTESKLSYY ; EYDFERGRRG ; 100: SKKGSVDIEK ; ITCVETVVPE ; NNPPPERQVP ; KKGEDYNMEQ ; ISIIERFPYP ; 150: FQVVYDEGPL ; YVFSPTEELR ; KRWIHQLKSV ; IRYNSDLVQK ; YHPCFWIDGQ ; 200: YLCCSQTAKN ; AMGCKILESR ; NGSLKAGRSH ; RKTKKPLPPT ; PEEDTMVMKP ; 250: LPPEPAPSAA ; GEMKKVVALY ; NYVPMNVQDL ; QLQKGEDYLI ; LEESHLPWWK ; 300: ARDKNGREGY ; IPSNYVTATS ; NSLEIYEWYS ; KNITRSQAEQ ; LLKQEGKEGG ; 350: FIVRDSTSKT ; GKYTVSVYAK ; SAVDPQGMIR ; HYVVCCTPQN ; QYYLAEKHLF ; 400: NTIPELITYH ; QHNSAGLISR ; LKYPVSRHQK ; SAPSTAGLGY ; GSWEIDPKDL ; 450: TFLKELGTGQ ; FGVVKYGKWR ; GQYNVAIKMI ; REGSMSEDEF ; IDEAKVMMNL ; 500: SHEKLVQLYG ; VCTKQRPIFI ; ITEYMANGCL ; LNFLRETQRR ; FQPAELLEMC ; 550: KDVCEAMEYL ; ESKQFLHRDL ; AARNCLVNDQ ; GIVKVSDFGL ; SRYVLDDEYT ; 600: SSMGSKFPVR ; WSPPEVLLYS ; KFSSKSDVWS ; FGVLMWEVYS ; LGKMPYERFN ; 650: NSETTEHVIQ ; GLRLYRPQQA ; SERVYAIMYS ; CWHEKAEERP ; TFSALLGSIV ; 657: DITDEEP
Sequence Length	657
String	Q8JH64
Sub Unit	Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain (By similarity). Interacts with IBTK via its PH domain (By similarity). Interacts with ARID3A, CAV1, FASLG, PIN1, TLR8 and TLR9.

Uniprot	Q8JH64
Gene Name	BTK
Immunogen Species	Gallus Gallus (Chicken)
Unigene	Gga.1305

Reference	1. "Btk expressed in primary chicken erythroblasts." Schmidt U., Haubenwallner S., Beug H., Nimpf J. Submitted (2002-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2." Takata M., Kurosaki T. J. Exp. Med.184:31-40(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PLCG2 3. "Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein." Yamadori T., Baba Y., Mastushita M., Hashimoto S., Kurosaki M., Kurosaki T., Kishimoto T., Tsukada S. Proc. Natl. Acad. Sci. U.S.A.96:6341-6346(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION 4. "Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation." Bajpai U.D., Zhang K., Teutsch M., Sen R., Wortis H.H. J. Exp. Med.191:1735-1744(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF THE ACTIVITY OF NF-KAPPA-B 5. "Differential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathway." Hao S., Kurosaki T., August A. EMBO J.22:4166-4177(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 6. "Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis." Uckun F.M. Biochem. Pharmacol.56:683-691(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION IN REGULATION OF APOPTOSIS 7. "Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain." Mohamed A.J., Yu L., Backesjo C.M., Vargas L., Faryal R., Aints A., Christensson B., Berglof A., Vihinen M., Nore B.F., Smith C.I. Immunol. Rev.228:58-73(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION;REVIEW ON ENZYME REGULATION

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