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Home / Assay Kits / ELISA Kits

ELISA Kit for Chicken Transcriptional coactivator YAP1

SKU : BHE13811680

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15210c
Alternative Names	65 kDa Yes-associated protein ; YAP65 ; Protein yorkie homolog ; YAP65
Categories	Elisa
Function	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
Specificity	Natural and recombinant Chicken Transcriptional coactivator YAP1
Subcellular Location	Cytoplasm Nucleus
Entryname	YAP1_CHICK
Platform	PF00397
Protein Name	Transcriptional coactivator YAP1
Sequence	50: MDPGQPQPQQ ; PPQAAQPPAP ; QQAAPQPPGA ; GSGAPGGAAQ ; PPGAGPPPAG ; 100: HQIVHVRGDS ; ETDLEALFNA ; VMNPKGANVP ; HTLPMRLRKL ; PDSFFKPPEP ; 150: KAHSRQASTD ; AGTAGALTPQ ; HVRAHSSPAS ; LQLGAVSPGT ; LTPSGVVTGP ; 200: GAPSSQHLRQ ; SSFEIPDDVP ; LPPGWEMAKT ; PSGQRYFLNH ; IDQTTTWQDP ; 250: RKAMLSQMNV ; TAPTSPPVQQ ; NLMNSASAMN ; QRISQSAPVK ; QPPPLAPQSP ; 300: QGGVMGGSSS ; NQQQQMRLQQ ; LQMEKERLRL ; KHQELLRQEL ; ALRSQLPTME ; 350: QDGGSQNPVS ; SPGMSQELRT ; MTTNSSDPFL ; NSGTYHSRDE ; STDSGLSMSS ; 400: YSVPRTPDDF ; LNSVDEMDTG ; DSISQSNIPS ; HQNRFPDYLE ; AIPGTNVDLG ; 448: TLEGDGMNIE ; GEELMPSLQE ; ALSSDILNDM ; ESVLAATKPD ; KESFLTWL
Sequence Length	448
String	P46936
Sub Unit	Binds to the SH3 domain of the YES kinase. Also binds to other signaling molecules that contain SH3 domains including Nck, Crk and Src.

Uniprot	P46936
Gene Name	YAP1
Immunogen Species	Gallus Gallus (Chicken)
Kegg	gga:396171
Unigene	Gga.3093

Reference	1. "Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product." Sudol M. Oncogene9:2145-2152(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] strain: White leghorn.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811680	E15210c	96T	$900		Add to Cart

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