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Home / Assay Kits / ELISA Kits

ELISA Kit for Chicken Transcription factor p65

SKU : BHE13811029

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0616c
Alternative Names	Nuclear factor NF-kappa-B p65 subunit
Categories	Elisa
Function	NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1.
Specificity	Natural and recombinant Chicken Transcription factor p65
Subcellular Location	Nucleus Cytoplasm Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor.
Entryname	TF65_CHICK
Platform	PF00554
Protein Name	Transcription factor p65
Sequence	50: MEPADLLPLY ; LQPEWGEQEP ; GGATPFVEIL ; EQPKQRGMRF ; RYKCEGRSAG ; 100: SIPGEHSTDS ; ARTHPTIRVN ; HYRGPGRVRV ; SLVTKDPPHG ; PHPHELVGRH ; 150: CQHGYYEAEL ; SPERCVHSFQ ; NLGIQCVKKR ; ELEAAVAERI ; RTNNNPFNVP ; 200: MEERGAEYDL ; SAVRLCFQVW ; VNGPGGLCPL ; PPVLSQPIYD ; NRAPSTAELR ; 250: ILPGDRNSGS ; CQGGDEIFLL ; CDKVQKEDIE ; VRFWAEGWEA ; KGSFAAADVH ; 300: RQVAIVFRTP ; PFRERSLRHP ; VTVRMELQRP ; SDRQRSPPLD ; FRYLPHQGDL ; 350: QCIEEKRKRT ; RDTFRAFVQR ; APLPGLEPNP ; EPRPPRRIAV ; PSRPPPAPQQ ; 400: PPSMVGAPPA ; PLFPLGVPPA ; SSPTPEPLAE ; ALLQLQFDDG ; VGGSGPPPST ; 450: TTTTTTTQCA ; LGGGIPDPGG ; SPLDLGALLG ; DPPFDTIDAA ; ELQRLLGPPE ; 500: TPPGGIGAGG ; GFGELLSLPT ; NFGDPPSSTA ; ATFGPSPPML ; LSYPEAITRL ; 550: VQCQTPGGSG ; GGGPPVGPPQ ; DLGGPLHPPG ; APPQPTEDSL ; PSLGDLDFSA ; 558: FLSQFPSS
Sequence Length	558
Sub Unit	Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-c-Rel complex. Component of the NF-kappa-B p65-p105 complex.

Uniprot	P98152
Gene Name	RELA
Immunogen Species	Gallus Gallus (Chicken)
Kegg	gga:396027
Unigene	Gga.604

Reference	1. "Isolation of the chicken NF-kappa B p65 subunit-encoding cDNA and characterization of its products." Ikeda T., Honjo K., Hirota Y., Onodera T. Gene133:237-242(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION IN THE NF-KAPPA-B P65-P50 COMPLEX;IDENTIFICATION IN THE NF-KAPPA-B P65-C-REL COMPLEX;IDENTIFICATION IN THE NF-KAPPA-B P65-P105 COMPLEX tissue: Spleen.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811029	E0616c	96T	$900		Add to Cart

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