ELISA Kit for Chicken Proheparin-binding EGF-like growth factor

Mfr.No.	E1479c
Alternative Names	HEGFL
Categories	Elisa
Function	May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibting the migration of the cranial neural crest cells (NCCs) migration into the odd-numbered neuromeres (r3 and r5) of the hindbrain. Plays a role in mediating v-Jun-induced oncogenic transformation.
Specificity	Natural and recombinant Chicken Proheparin-binding EGF-like growth factor
Subcellular Location	Proheparin-binding EGF-like growth factor Cell membrane Single-pass type I membrane protein
Entryname	HBEGF_CHICK
Platform	PF00008
Protein Name	Proheparin-binding EGF-like growth factor
Sequence	50: MDGRVVLIHA ; LLTAVCSAAV ; GKFGRDGPHG ; EALHNEVLLH ; EGGGVASVSA ; 100: TAPLLGGIVE ; KEGGGAASGD ; ALSELPRVAF ; LSKPQGPVTP ; KKKGNGNKRR ; 150: KGKGLGKKRD ; PCLRKYKDFC ; IHGECKYIRE ; LGAPSCICQP ; GYHGERCHGL ; 200: LLPVEHPPST ; YDHTTALAVV ; AVVLSSLCLV ; IITALLMFRC ; HKRGVYDVEN ; 212: EEKIKLGITV ; NH
Sequence Length	212
String	Q9W7C5
Sub Unit	Interacts with CNIH2.

Reference	1. "Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation." Fu S., Bottoli I., Goller M., Vogt P.K. Proc. Natl. Acad. Sci. U.S.A.96:5716-5721(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INDUCTION strain: White leghorn. 2. "Cornichon-like protein facilitates secretion of HB-EGF and regulates proper development of cranial nerves." Hoshino H., Uchida T., Otsuki T., Kawamoto S., Okubo K., Takeichi M., Chisaka O. Mol. Biol. Cell18:1143-1152(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION INTERACTION WITH CNIH2;DEVELOPMENTAL STAGE

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805124	E1479c	96T	$900		Add to Cart