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ELISA Kit for Chicken Nuclear factor NF-kappa-B p100 subunit

SKU : BHE13808149

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9393c
Alternative Names	DNA-binding factor KBF2 ; Lyt-10 ; Nuclear factor NF-kappa-B p97 subunit ; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
Categories	Elisa
Function	NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions.
Specificity	Natural and recombinant Chicken Nuclear factor NF-kappa-B p100 subunit
Subcellular Location	Nucleus Cytoplasm Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Entryname	NFKB2_CHICK
Method Type	Sandwich
Platform	PF00023
Protein Name	Nuclear factor NF-kappa-B p100 subunit
Sequence	50: MDEHFQPCLD ; GIDYDDFSFG ; SHMVEQKEPL ; METAVGPYLV ; IIEQPKQRGF ; 100: RFRYVCEGPS ; HGGLPGASSE ; KGHKTYPTVK ; ICNYEGMARI ; EVDLVTHSDP ; 150: PRVHAHSLVG ; KQCNEAGNCV ; AIVGPKDMTA ; QFSNLGVLHV ; TKKNMMEIMK ; 200: EKLKKQKTRN ; TNGLLTEAEL ; REIELEAKEL ; KKVMDLSIVR ; LRFTAYLRDS ; 250: SGNFTLALQP ; VISDPIHDSK ; SPGASNLKIS ; RMDKTAGSVR ; GGDEVYLLCD ; 300: KVQKDDIEVR ; FYEDDENGWQ ; ASGDFSPTDV ; HKQYAIVFRT ; PPYHKPKIDR ; 350: PVTVFLQLKR ; KRGGDVSDSK ; QFTYYPVVED ; KEEVERNRKK ; VLPQFPQHFG ; 400: GGSHMGGAGG ; AGGFGAGGGG ; NLSFPYSSGL ; GYNNLYSSSP ; HPVGCGYQGG ; 450: VQMKAASERD ; GDDRQAPTES ; TYCRELQRHR ; HLCHLWLLAR ; RNAHALLDYS ; 500: VTADPRMLLA ; VQRHLAASQD ; ENGDTPLHLA ; IIHEQTAVIK ; QLIEVVVSIP ; 550: SQQIINITNN ; LQQTPLHLAV ; ITKQPQVVQL ; LLEAHANPTL ; LDRYGNSLLH ; 600: LALQAADEEM ; LRMLLAHLAS ; ATPYLLHLPN ; FQGLLPVHLA ; VKAKSPACLD ; 650: LLVRKGADVN ; GVERQGGRTP ; LHLAVEMENL ; NMATHLVKKL ; GANVNSRTFA ; 700: GNTPLHLAAG ; LGSPTLTKLL ; LKAGADVQRE ; NDEPVSPSSV ; RVPSSDTDGD ; 750: PEEQEQEQAM ; ELGEPALSPH ; PTPEEEQEEA ; GPRQRLHTAL ; DLTRSQKVRD ; 800: ILLQASQPSP ; PILSCPPPPS ; RNHLLSLDTD ; ALQGLEQLLN ; QYGSGSDWME ; 850: LAKRLGLCSL ; VETYKTTPSP ; ASALRSYELP ; GGSLGGLLEA ; LDSMGLRGAV ; 900: RMLRKPEPLE ; KLQSTEVKED ; SAYGSESVEE ; EQAARLKPRP ; VPEGELPHSQ ; 906: QQQQVH
Sequence Length	906
String	P98150
Sub Unit	Component of the NF-kappa-B RelB-p52 complex.

Uniprot	P98150
Gene Name	NFKB2
Immunogen Species	Gallus Gallus (Chicken)
Kegg	gga:386574
Unigene	Gga.1057

Reference	1. "The chicken RelB transcription factor has transactivation sequences and a tissue-specific expression pattern that are distinct from mammalian RelB." Piffat K.A., Hrdlickova R., Nehyba J., Ikeda T., Liss A., Huang S., Sif S., Gilmore T.D., Bose H.R. Jr. Mol. Cell Biol. Res. Commun.4:266-275(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NF-KAPPA-B RELB-P52 COMPLEX 2. "NF-kappa B p100 is one of the high-molecular-weight proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells." Sif S., Gilmore T.D. J. Virol.67:7612-7617(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Fibroblast. 3. "Isolation of a cDNA encoding the chicken p50B/p97 (Lyt-10) transcription factor." Ikeda T., Hirota Y., Onodera T. Gene138:193-196(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Spleen.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808149	E9393c	96T	$900		Add to Cart

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