Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
Specificity
Natural and recombinant Chicken Indian hedgehog protein
Subcellular Location
Indian hedgehog protein C-product Secreted extracellular space The C-terminal peptide diffuses from the cell.