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Home / Assay Kits / ELISA Kits

ELISA Kit for Chicken Fibroblast growth factor receptor 1

SKU : BHE13804228

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0074c
Alternative Names	Basic fibroblast growth factor receptor 1 ; Tyrosine kinase receptor CEK1 ; CEK1
Categories	Elisa
Function	Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2A, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2A triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation.
Specificity	Natural and recombinant Chicken Fibroblast growth factor receptor 1
Subcellular Location	Cell membrane Single-pass type I membrane protein Nucleus Cytoplasm cytosol Cytoplasmic vesicle After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
Detection Range	78-5000pg/mL
Entryname	FGFR1_CHICK
Method Type	Sandwich
Platform	PF07679
Protein Name	Fibroblast growth factor receptor 1
Sensitivity	39pg/mL
Sequence	50: MFTWRCLILW ; AVLVTATLSA ; ARPAPTLPDQ ; ALPKANIEVE ; SHSAHPGDLL ; 100: QLRCRLRDDV ; QSINWVRDGV ; QLPENNRTRI ; TGEEVEVRDA ; VPEDSGLYAC ; 150: MTNSPSGSET ; TYFSVNVSDA ; LPSAEDDDDE ; DDSSSEEKEA ; DNTKPNQAVA ; 200: PYWTYPEKME ; KKLHAVPAAK ; TVKFKCPSGG ; TPNPTLRWLK ; NGKEFKPDHR ; 250: IGGYKVRYAT ; WSIIMDSVVP ; SDKGNYTCIV ; ENKYGSINHT ; YQLDVVERSP ; 300: HRPILQAGLP ; ANKTVALGSN ; VEFVCKVYSD ; PQPHIQWLKH ; IEVNGSKIGP ; 350: DNLPYVQILK ; TAGVNTTDKE ; MEVLHLRNVS ; FEDAGEYTCL ; AGNSIGISHH ; 400: SAWLTVLEAT ; EQSPAMMTSP ; LYLEIIIYCT ; GAFLISCMVV ; TVIIYKMKST ; 450: TKKTDFNSQL ; AVHKLAKSIP ; LRRQVTVSAD ; SSSSMNSGVM ; LVRPSRLSSS ; 500: GTPMLAGVSE ; YELPEDPRWE ; LPRDRLILGK ; PLGEGCFGQV ; VLAEAIGLDK ; 550: DKPNRVTKVA ; VKMLKSDATE ; KDLSDLISEM ; EMMKMIGKHK ; NIINLLGACT ; 600: QDGPLYVIVE ; YASKGNLREY ; LQARRPPGME ; YCYNPTRIPE ; EQLSFKDLVS ; 650: CAYQVARGME ; YLASKKCIHR ; DLAARNVLVT ; EDNVMKIADF ; GLARDIHHID ; 700: YYKKTTNGRL ; PVKWMAPEAL ; FDRIYTHQSD ; VWSFGVLLWE ; IFTLGGSPYP ; 750: GVPVEELFKL ; LKEGHRMDKP ; SNCTNELYMM ; MRDCWHAVPS ; QRPTFKQLVE ; 800: DLDRIVAMTS ; NQEYLDLSVP ; LDQYSPGFPA ; TRSSTCSSGE ; DSVFSHDPLP ; 819: DEPCLPRCPP ; HSHGALKRH
Sequence Length	819
String	P21804
Sub Unit	Monomer. Homodimer after ligand binding.

Uniprot	P21804
Gene Name	FGFR1
Immunogen Species	Gallus Gallus (Chicken)
Kegg	gga:396516
Unigene	Gga.47947

Reference	1. "Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library." Pasquale E.B., Singer S.J. Proc. Natl. Acad. Sci. U.S.A.86:5449-5453(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. Pasquale E.B. Submitted (1989-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION 3. "Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor." Lee P.L., Johnson D.E., Cousens L.S., Fried V.A., Williams L.T. Science245:57-60(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804228	E0074c	96T	$900		Add to Cart

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