ELISA Kit for Chicken Apoptosis regulator Bcl-2

Mfr.No.	E0778c
Alternative Names	BCL-2
Categories	Elisa
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Specificity	Natural and recombinant Chicken Apoptosis regulator Bcl-2
Subcellular Location	Mitochondrion outer membrane Single-pass membrane protein Nucleus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein
Detection Range	0.78-50ng/mL
Entryname	BCL2_CHICK
Method Type	Sandwich
Platform	PF00452
Protein Name	Apoptosis regulator Bcl-2
Sensitivity	0.27ng/mL
Sequence	50: MAHPGRRGYD ; NREIVLKYIH ; YKLSQRGYDW ; AAGEDRPPVP ; PAPAPAAAPA ; 100: AVAAAGASSH ; HRPEPPGSAA ; ASEVPPAEGL ; RPAPPGVHLA ; LRQAGDEFSR ; 150: RYQRDFAQMS ; GQLHLTPFTA ; HGRFVAVVEE ; LFRDGVNWGR ; IVAFFEFGGV ; 200: MCVESVNREM ; SPLVDNIATW ; MTEYLNRHLH ; NWIQDNGGWD ; AFVELYGNSM ; 233: RPLFDFSWIS ; LKTILSLVLV ; GACITLGAYL ; GHK
Sequence Length	233
String	Q00709
Sub Unit	Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Also interacts with APAF1 and RAF-1.

Reference	1. "Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo." Eguchi Y., Ewert D.L., Tsujimoto Y. Nucleic Acids Res.20:4187-4192(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 2. "Molecular cloning and DNA sequence analysis of cDNA encoding chicken homologue of the Bcl-2 oncoprotein." Cazals-Hatem D.L., Louie D.C., Tanaka S., Reed J.C. Biochim. Biophys. Acta1132:109-113(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: B-cell lymphoma.

Have you used this product?

SKU	Supplier No.	Size	Your price	Quantity
BHE13801487	E0778c	96T	$900		Add to Cart