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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Tyrosine-protein phosphatase non-receptor type substrate 1

SKU : BHE13810736

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9001b
Alternative Names	CD172 antigen-like family member A ; Inhibitory receptor SHPS-1 ; MyD-1 antigen ; Signal-regulatory protein alpha-1 ; Sirp-alpha-1 ; CD172a ; MYD1 ; PTPNS1 ; SHPS1 ; SIRP
Categories	Elisa
Function	Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Specificity	Natural and recombinant Bovine Tyrosine-protein phosphatase non-receptor type substrate 1
Subcellular Location	Membrane Single-pass type I membrane protein
Entryname	SHPS1_BOVIN
Platform	PF07654
Protein Name	Tyrosine-protein phosphatase non-receptor type substrate 1
Sequence	50: MEPARPAPGR ; LRPLLCLLLA ; ASNAWTGTAG ; DGELQVIQPE ; RSVSVAAGET ; 100: ATLHCTVTSL ; SPVGPIKWFK ; GTGPGREFIY ; SQKEAPFPRV ; TNVSDATKRN ; 150: NMDFSIRISN ; ITPADAGVYY ; CVKFRKEERG ; DMEFKSGPGT ; HLTVSAKPSP ; 200: PVLSGPTVRA ; TPEQTVNFTC ; TSHGFSPRNI ; SLKWFKNGNE ; LSASQTSVDP ; 250: EDNNVSYSIN ; STTKVLLATG ; DVHSQVICEV ; AHVTLQGGPP ; LRGTANLSET ; 300: IRVPPTLEIT ; GSPSAGNQVN ; VTCQVNKFYP ; RHLQLTWLEN ; GNMSRTEAAS ; 350: VFVENKDGTF ; NQTSWFLVNS ; SAHREAVVLT ; CQVEHDGQPA ; VSKNHTLEVS ; 400: APQKDQDTGQ ; TPGPNDSNWT ; SIFIVVGVVC ; ALLVALLIAA ; LYLLRIRQNK ; 450: AKGSTSSTRL ; HEPEKNTRET ; TQIQDNNDIT ; YADLNLPKGK ; KSTPKANEPN ; 500: NHTEYASIQA ; RPPPVSEDTL ; TYADLDMVHL ; NRTPKQPAPK ; PEPSYSEYAS ; 506: VQVQRK
Sequence Length	506
String	O46631
Sub Unit	Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds FGR and PTK2B.

Uniprot	O46631
Gene Name	SIRPA
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:327666
Unigene	Bt.64590

Reference	1. "Cloning of two members of the SIRP alpha family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells." Brooke G.P., Parsons K.R., Howard C.J. Eur. J. Immunol.28:1-11(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS SER-23; ALA-28; LEU-61; ARG-70; HIS-120; 125-GLN; 127-GLY; 129-HIS; 132-VAL; ASN-145; VAL-153; ASP-203; ARG-261; LEU-302; LEU-316; ARG-337; ASN-367; LEU-422; PHE-429 AND GLU-433 strain: Friesian. tissue: Peripheral blood.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810736	E9001b	96T	$900		Add to Cart

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