Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Specificity
Natural and recombinant Bovine Toll-like receptor 4
Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4 (By similarity). Interacts with CNPY3.
"Bovine Toll-like receptor 4 (TLR4)." Guionaud C.T., Dubey C., Jungi T.W. Submitted (2001-11) to the EMBL/GenBank/DDBJ databases
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2.
"Role of bovine TLRs in antigen presentation." Werling D., McGuire K., Glass E. Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
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3.
"cDNA cloning and sequence analysis of signalling molecules on bovine toll-like receptors." Wang X.P., Xu S.Z., Gao X., Ma T.H., Ren H.Y., Chen J.B. Submitted (2006-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]