ELISA Kit for Bovine Toll-interacting protein

Mfr.No.	E15227b
Categories	Elisa
Function	Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.
Specificity	Natural and recombinant Bovine Toll-interacting protein
Subcellular Location	Cytoplasm
Entryname	TOLIP_BOVIN
Platform	PF00168
Protein Name	Toll-interacting protein
Sequence	50: MATTVSTQRG ; PVYIGELPQD ; FLRITPTQQQ ; QQIQLDAQAA ; QQLQYGGALG ; 100: TVGRLSVTVV ; QAKLAKNYGM ; TRMDPYCRLR ; LGYAVYETPT ; AHNGAKNPRW ; 150: NKVIQCTVPP ; GVDSFYLEIF ; DERAFSMDDR ; IAWTHVTIPE ; ALKQGKVVDE ; 200: WYSLSGRQGD ; DKEGMINLVL ; SYTSLPAAMM ; MPPQPVVLMP ; TVYQQGVGYV ; 250: PITGMPTVCS ; PGVVPVALPP ; AVSAQPRCSE ; EDLKAIQDMF ; PNMDREVIRS ; 273: VLEAQRGSRD ; AAINSLLQMG ; EES
Sequence Length	273
String	Q2LGB5
Sub Unit	Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2.

Reference	1. "Cloning and radiation hybrid mapping of bovine toll-like receptor-4 (TLR-4) signaling molecules." Connor E.E., Cates E.A., Williams J.L., Bannerman D.D. Vet. Immunol. Immunopathol.112:302-308(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Mammary gland. 2. "Identification of signalling molecules involved in bovine TLR signalling." Werling D., Willcocks S. Submitted (2006-02) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics6:166-166(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 4. NIH - Mammalian Gene Collection (MGC) project Submitted (2006-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Hereford. tissue: Hippocampus.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811296	E15227b	96T	$900		Add to Cart