Neuron-specific antigen HPC-1 ; Synaptotagmin-associated 35 kDa protein ; P35A
Categories
Elisa
Function
Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Specificity
Natural and recombinant Bovine Syntaxin-1A
Subcellular Location
Cytoplasmic vesicle secretory vesicle synaptic vesicle membrane Single-pass type IV membrane protein Cell junction synapse synaptosome
Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Interacts with OTOF, LGI3, VAPA and SYBU. Binds SYTL4 and STXBP6. Found in a complex with VAMP8 and SNAP23. Found in a ternary complex with STX1A and SNAP25. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity). Interacts with SLC6A4.
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