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ELISA Kit for Bovine Serine/threonine-protein kinase PLK1

SKU : BHE13809434

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1662b
Alternative Names	Polo-like kinase 1 ; PLK-1
Categories	Elisa
Function	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Phosphorylates NEDD1. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.
Specificity	Natural and recombinant Bovine Serine/threonine-protein kinase PLK1
Subcellular Location	Nucleus Chromosome centromere kinetochore Cytoplasm cytoskeleton centrosome During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization.
Entryname	PLK1_BOVIN
Platform	PF00069
Protein Name	Serine/threonine-protein kinase PLK1
Sequence	50: MSAAATAGKL ; GRAPADPGKA ; PGVAAPGAST ; AAPPAKEIPE ; VLVDPRSRRR ; 100: YLRGRFLGKG ; GFAKCFEISD ; ADTKEVFAGK ; IVPKSLLLKP ; HQKEKMSMEI ; 150: SIHRSLAHQH ; VVGFHGFFED ; NDFVFVVLEL ; CRRRSLLELH ; KRRKALTEPE ; 200: ARYYLRQIVL ; GCQYLHGNRV ; IHRDLKLGNL ; FLNEDLEVKI ; GDFGLATKVE ; 250: YDGERKKTLC ; GTPNYIAPEV ; LSKKGHSFEV ; DVWSIGCIMY ; TLLVGKPPFE ; 300: TSCLKETYLR ; IKNNEYSIPK ; HINPVASSLI ; KKMLQPDPTA ; RPTIHELLND ; 350: EFFTSGYIPA ; RLPITCLTIP ; PRFSIAPSSL ; DPSNRKPLTV ; LNKGMENPMP ; 400: ERPREKEEPV ; VREASEPVDC ; HLSDMLQQLH ; SVNASKPSER ; GLVRQEEAED ; 450: PACIPIFWVS ; KWVDYSDKYG ; LGYQLCDNSV ; GVLFNDSTRL ; ILYSDGDSLQ ; 500: YIERDGSESY ; LTVSSHPNSL ; IKKITLLKYF ; RNYMSEHLLK ; AGANITPREG ; 550: DELARLPYLR ; TWFRTRSAII ; LHLSNGCEQI ; NFFQDHTKLI ; LCPLMAAVTY ; 600: IDEKRDFRTY ; RLSLLEEYGC ; SKELASRLRY ; ARAMVDKLLS ; SRSAANRLKA ; 602: SS
Sequence Length	602
String	Q2TA25
Sub Unit	Interacts with CEP170 and EVI5. Interacts and phosphorylates ERCC6L. Interacts with FAM29A. Interacts with SLX4/BTBD12 and TTDN1. Interacts with BUB1B. Interacts (via POLO-box domain) with the phosphorylated form of BUB1, MLF1IP and CDC25C. Interacts with BORA, KIF2A and AURKA. Interacts with TOPORS and CYLD.

Uniprot	Q2TA25
Gene Name	PLK1
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:538238
Unigene	Bt.14093

Reference	1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution." The bovine genome sequencing and analysis consortium Science324:522-528(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: Hereford. 2. NIH - Mammalian Gene Collection (MGC) project Submitted (2005-12) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Crossbred X Angus. tissue: Liver.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809434	E1662b	96T	$900		Add to Cart

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