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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Ribosomal protein S6 kinase beta-1

SKU : BHE13806203

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3119b
Alternative Names	70 kDa ribosomal protein S6 kinase 1 ; P70S6K1
Categories	Elisa
Function	Acts to integrate nutrient and growth factor signals in regulation of protein synthesis, cell proliferation, cell growth, cell cycle progression and cell survival. Downstream effector of the mTOR signaling pathway. Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. During translation initiation, the inactive form interacts with the eIF-3 complex under conditions of nutrient depletion. Mitogenic stimulation leads to phosphorylation and dissociation from the eIF-3 complex and the free activated form can phosphorylate other translational targets including EIF4B. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation. Phosphorylates RICTOR leading to regulation of mammalian target of rapamycin complex 2 (mTORC2) signaling. Phosphorylates IRS1 at multiple serine residues coupled with insulin resistance. Required for TNF-alpha induced IRS-1 degradation. Phosphorylates EEF2K in response to IGF1 and inhibits EEF2K activity. Phosphorylates BAD in response to IGF1 leading to BAD inactivation and inhibition of BAD-induced apoptosis. Phosphorylates mitochondrial RMP leading to dissociation of a RMP:PPP1CC complex. The free mitochondrial PPP1CC can dephosphorylate RPS6KB1 at Thr-412 which is proposed to be a negative feed back mechanism for the RPS6KB1 antiapoptotic function. Phosphorylates POLDIP3.
Specificity	Natural and recombinant Bovine Ribosomal protein S6 kinase beta-1
Subcellular Location	Cytoplasm Cell junction synapse synaptosome Mitochondrion outer membrane
Entryname	KS6B1_BOVIN
Platform	PF00069
Protein Name	Ribosomal protein S6 kinase beta-1
Sequence	50: MRRRRRRDGF ; YPAPDFRDRE ; AEDMAGVFDI ; DLDQPEDAGS ; EDELEEGGQL ; 100: NESMDHGGVG ; PYELGMEHCE ; KFEISETSVN ; RGPEKIRPEC ; FELLRVLGKG ; 150: GYGKVFQVRK ; VTGANTGKIF ; AMKVLKKAMI ; VRNAKDTAHT ; KAERNILEEV ; 200: KHPFIVDLIY ; AFQTGGKLYL ; ILEYLSGGEL ; FMQLEREGIF ; MEDTACFYLA ; 250: EISMALGHLH ; QKGIIYRDLK ; PENIMLNHQG ; HVKLTDFGLC ; KESIHDGTVT ; 300: HTFCGTIEYM ; APEILMRSGH ; NRAVDWWSLG ; ALMYDMLTGA ; PPFTGENRKK ; 350: TIDKILKCKL ; NLPPYLTQEA ; RDLLKKLLKR ; NAASRLGAGP ; GDAGEVQAHP ; 400: FFRHINWEEL ; LARKVEPPFK ; PLLQSEEDVS ; QFDSKFTRQT ; PVDSPDDSAL ; 450: SESANQVFLG ; FTYVAPSVLE ; SVKEKFSFEP ; KIRSPRRFIG ; SPRTPVSPVK ; 500: FSPGDFWGRG ; ASASTANPQT ; PVEYPMETSG ; IEQMDVTMSG ; EASAPLPIRQ ; 527: PNSGPYKKQA ; FPMISKRPEH ; LRMNLEL
Sequence Length	527
String	Q6TJY3
Sub Unit	Interacts with PPP1R9A/neurabin-1. Interacts with RPTOR. Interacts with IRS1. Interacts with EIF3B and EIF3C. Interacts with POLDIP3 and TRAF4.

Uniprot	Q6TJY3
Gene Name	RPS6KB1
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:404181
Unigene	Bt.41950

Reference	1. Arvisais E.W., Davis J.S. Submitted (2003-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806203	E3119b	96T	$900		Add to Cart

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