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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Rho-associated protein kinase 1

SKU : BHE13809737

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15189b
Alternative Names	Rho-associated ; coiled-coil-containing protein kinase 1 ; Rho-associated ; coiled-coil-containing protein kinase I ; ROCK-I ; p160 ROCK-1 ; p160ROCK
Categories	Elisa
Function	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation.
Specificity	Natural and recombinant Bovine Rho-associated protein kinase 1
Subcellular Location	Cytoplasm Golgi apparatus membrane Peripheral membrane protein Cytoplasm cytoskeleton centrosome centriole Cell projection bleb A small proportion is associated with Golgi membranes (By similarity). Associated with the mother centriole and an intercentriolar linker.
Entryname	ROCK1_BOVIN
Platform	PF08912
Protein Name	Rho-associated protein kinase 1
Sequence	50: NSKSQMDKDY ; YQLQAVLEAE ; RRDRGHDSEK ; IGDLQARITS ; LQEEVKHLKH ; 100: NLERVEGERK ; EAQDMLNHSE ; KEKNNLEIDL ; NYKLKSLQQR ; LEQEVNEHKV ; 150: TKARLTDKHQ ; SIEEAKSVAM ; CEMEKKLKEE ; RDAREKAENR ; VVQIEKQCSM ; 200: LDVDLKQSQQ ; KLEHLIENKD ; RMEDEVKNLT ; LQLEQESNKR ; LLLQNELKTQ ; 250: AFEADNLKGL ; EKQMKQEINT ; LLEAKRLLEF ; ELAQLTKQYR ; GNEGQMRELQ ; 300: DQLEAEQYFS ; TLYKTQVKEL ; KEEIEEKNRE ; NLKKIQELQS ; EKETLATQLD ; 350: LAETKAESEQ ; LARGLLEEQY ; FELTQESKKA ; ASRNRQEITD ; KDHTLSRLEE ; 400: TNSMLTKDIE ; LLRKENEELT ; DKMRKAEEEY ; KLKKEEEINI ; LKAAFEKNIN ; 441: TERTLKTQAV ; NKLAEIMNRK ; DFKIDRKKAN ; TQDLRKKKKK ; K
Sequence Length	441
String	Q8MIT6
Sub Unit	Homodimer (By similarity). Interacts with RHOA (activated by GTP), RHOB, RHOC, GEM, MYLC2B, RHOE, PPP1R12A, LIMK1, LIMK2, TSG101, CHORDC1, DAPK3, PFN1, PTEN and JIP3 (By similarity). Interacts with FHOD1 in a Src-dependent manner.

Uniprot	Q8MIT6
Gene Name	ROCK1
Immunogen Species	Bos Taurus (Cattle)
Unigene	Bt.65075

Reference	1. "The Rho-associated protein kinase p160ROCK is required for centrosome positioning." Chevrier V., Piel M., Collomb N., Saoudi Y., Frank R., Paintrand M., Narumiya S., Bornens M., Job D. J. Cell Biol.157:807-817(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION tissue: Kidney. 2. "Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase." Kosako H., Amano M., Yanagida M., Tanabe K., Nishi Y., Kaibuchi K., Inagaki M. J. Biol. Chem.272:10333-10336(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 3. "Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension." Uehata M., Ishizaki T., Satoh H., Ono T., Kawahara T., Morishita T., Tamakawa H., Yamagami K., Inui J., Maekawa M., Narumiya S. Nature389:990-994(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;INHIBITION BY Y-27632;FUNCTION

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809737	E15189b	96T	$900		Add to Cart

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