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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Receptor-interacting serine/threonine-protein kinase 2

SKU : BHE13809676

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1786b
Alternative Names	Tyrosine-protein kinase RIPK2 ; 2.7.10.2
Categories	Elisa
Function	Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is release from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Specificity	Natural and recombinant Bovine Receptor-interacting serine/threonine-protein kinase 2
Subcellular Location	Cytoplasm
Entryname	RIPK2_BOVIN
Platform	PF00619
Protein Name	Receptor-interacting serine/threonine-protein kinase 2
Sequence	50: MSAEPVCSAL ; PAIPYHKLAD ; LRYLSRGASG ; TVSSARHADW ; RVQVAVKHLH ; 100: IHSPLLDSER ; NDVLREAEIL ; HKARFSYILP ; ILGICNEPEF ; LGIVTEYMPN ; 150: GSLNELLHRK ; IEYPDVPWPL ; RFRILHEIAL ; GVNYLHNMNP ; PLLHHDLKTQ ; 200: NILLDNEFHV ; KIADFGLSKW ; RMMSLSQSRS ; SKSAPEGGTI ; VYMPPENYEP ; 250: GQKARASVKH ; DIYSYAIIIW ; EVLSRKQPFE ; DVTNPLQIMY ; SVSQGHRPDT ; 300: NEESLPFDIP ; HRALMISLIE ; SGWAQNPDER ; PSFLKCLIEL ; EPVLRTFEEI ; 350: TFLEAVIQLK ; KTKLQNASRT ; VHLSDKKKRE ; LSPNIPVNSG ; PREESCGSSQ ; 400: LHKTSGSPGT ; SRSLSAPQDK ; DFLSAKTQDF ; SALHQCSVNH ; SRNSDFCVDC ; 450: QVAFCDHRTA ; PCSLAIVNPL ; SAEGNSGRFQ ; PGIAQQWIQS ; KREDIVSQMT ; 500: EACLNQSLDA ; LLSRDLIMKE ; DYELISTKPT ; RTSKVRQLLD ; TTDIQGEEFA ; 540: RVIVQKLKDN ; KQMGLQPYPE ; ILVLSQSPSL ; NFFHNKSHKK ;
Sequence Length	540
String	Q3SZJ2
Sub Unit	Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex. Interacts with NOD1 and NOD2.

Uniprot	Q3SZJ2
Gene Name	RIPK2
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:534407
Unigene	Bt.34596

Reference	1. NIH - Mammalian Gene Collection (MGC) project Submitted (2005-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Crossbred X Angus. tissue: Ileum.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809676	E1786b	96T	$900		Add to Cart

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