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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine RAC-alpha serine/threonine-protein kinase

SKU : BHE13800051

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0382b
Alternative Names	Protein kinase B ; PKB ; Protein kinase B alpha ; PKB alpha ; RAC-PK-alpha ; PKB
Categories	Elisa
Function	AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
Specificity	Natural and recombinant Bovine RAC-alpha serine/threonine-protein kinase
Subcellular Location	Cytoplasm Nucleus Cell membrane Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A (By similarity). Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus.
Detection Range	0.312-20ng/mL
Entryname	AKT1_BOVIN
Method Type	Sandwich
Platform	PF00169
Protein Name	RAC-alpha serine/threonine-protein kinase
Sensitivity	0.099ng/mL
Sequence	50: MNDVAIVKEG ; WLHKRGEYIK ; TWRPRYFLLK ; NDGTFIGYKE ; RPQDLEQRES ; 100: PLNNFSVAQC ; QLMKTERPRP ; NTFIIRCLQW ; TTVIERTFHV ; ETPEEREEWT ; 150: TAIQTVADGL ; KRQEEETMDF ; RSGSPGENSG ; AEEMEVSLAK ; PKHRVTMNDF ; 200: EYLKLLGKGT ; FGKVILVKEK ; ATGRYYAMKI ; LKKEVIVAKD ; EVAHTLTENR ; 250: VLQNSRHPFL ; TALKYSFQTH ; DRLCFVMEYA ; NGGELFFHLS ; RERVFSEDRA ; 300: RFYGAEIVSA ; LDYLHSEKEV ; VYRDLKLENL ; MLDKDGHIKI ; TDFGLCKEGI ; 350: KDGATMKTFC ; GTPEYLAPEV ; LEDNDYGRAV ; DWWGLGVVMY ; EMMCGRLPFY ; 400: NQDHEKLFEL ; ILMEEIRFPR ; TLSPEAKSLL ; SGLLKKDPKQ ; RLGGGSEDAK ; 450: EIMQHRFFAS ; IVWQDVYEKK ; LSPPFKPQVT ; SETDTRYFDE ; EFTAQMITIT ; 480: PPDQDDSMEG ; VDSERRPHFP ; QFSYSASATA ;
Sequence Length	480
String	Q01314
Sub Unit	Interacts (via the C-terminus) with CCDC88A (via its C-terminus) and THEM4 (via its C-terminus). Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with TRAF6. Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE binding. Interacts with RARA; the interaction phosphorylates RARA and represses its transactivation activity (By similarity). Interacts with MAP3K5 and TNK2 (By similarity). Interacts with CLK2 and PPP2R5B (By similarity). Interacts with STK3/MST2 and STK4/MST1.

Uniprot	Q01314
Gene Name	AKT1
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:280991
Unigene	Bt.4843

Reference	1. "Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families." Coffer P.J., Woodgett J.R. Eur. J. Biochem.201:475-481(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 2. Coffer P.J., Woodgett J.R. Eur. J. Biochem.205:1217-1218(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION 3. "Complete sequence of the bovine AKT1 gene." Khatib H. Submitted (2004-10) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 4. "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth." Gao T., Furnari F., Newton A.C. Mol. Cell18:13-24(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEPHOSPHORYLATION AT SER-473 BY PHLPP

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800051	E0382b	96T	$900		Add to Cart

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