Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.
Specificity
Natural and recombinant Bovine Protein prune homolog
Homooligomer (By similarity). Able to homodimerize via its C-terminal domain (By similarity). Interacts with NME1 (By similarity). Interacts with GSK3; at focal adhesion complexes where paxillin and vinculin are colocalized.