Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Specificity
Natural and recombinant Bovine POU domain, class 5, transcription factor 1
Subcellular Location
Nucleus Expressed in a diffuse and slightly punctuate pattern.
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Reviews of ELISA Kit for Bovine POU domain, class 5, transcription factor 1