Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.
Specificity
Natural and recombinant Bovine Polypyrimidine tract-binding protein 1
"Cloning and characterization of bovine mRNA encoding polypyrimidine-tract binding protein (PTB)." Guibert S., Julien R., Oulmouden A. Submitted (2001-11) to the EMBL/GenBank/DDBJ databases
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