ELISA Kit for Bovine PCNA-associated factor

Mfr.No.	E8921b
Alternative Names	PCNA-associated factor of 15 kDa ; PAF15 ; PCNA-clamp-associated factor ; PAF
Categories	Elisa
Function	PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Specificity	Natural and recombinant Bovine PCNA-associated factor
Subcellular Location	Nucleus Cytoplasm Perinuclear region Following DNA damage, localizes to DNA damage sites. Colocalizes with centrosomes in perinuclear region.
Entryname	PAF15_BOVIN
Protein Name	PCNA-associated factor
Sequence	50: MVRTKANSVP ; GSYRKVVASR ; APRKVLGSST ; SAANSTPLSS ; RKAENKYAGG ; 100: NPVCVRPTPK ; WQKGIGEFFS ; LSPKDSEKEN ; RIPEEAGSSG ; LGKAKRKACP ; 111: LPPDHTDDEK ; E
Sequence Length	111
Sub Unit	Interacts (when monoubiquitinated at Lys-15 and Lys-24) with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1.

Reference	1. "Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics6:166-166(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 2. NIH - Mammalian Gene Collection (MGC) project Submitted (2005-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Crossbred X Angus. tissue: Ileum.

Have you used this product?

SKU	Supplier No.	Size	Your price	Quantity
BHE13808032	E8921b	96T	$900		Add to Cart