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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine NAD-dependent protein deacetylase sirtuin-7

SKU : BHE13810221

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11385b
Alternative Names	Regulatory protein SIR2 homolog 7 ; SIR2-like protein 7
Categories	Elisa
Function	NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
Specificity	Natural and recombinant Bovine NAD-dependent protein deacetylase sirtuin-7
Subcellular Location	Cytoplasm Nucleus Nucleolus Located close to the nuclear membrane when in the cytoplasm (By similarity). Associated with chromatin (By similarity). Associated with rDNA promoter and transcribed region (By similarity). Associated with nucleolar organizer regions during mitosis.
Entryname	SIR7_BOVIN
Method Type	Sandwich
Platform	PF02146
Protein Name	NAD-dependent protein deacetylase sirtuin-7
Sequence	50: MAAGGLSRSE ; RKAAERVRRL ; REEQQRERLR ; QVSRILRKAA ; TERSAEEGRL ; 100: LAESEDLVTE ; LQGRSRRREG ; LKRRQEEVCD ; DPEELQRKVR ; ELASAVRNAK ; 150: YLVVYTGAGI ; STAASIPDYR ; GPNGVWTLLQ ; KGRSVSAADL ; SEAEPTLTHM ; 200: SITRLHEQKL ; VQHVVSQNCD ; GLHLRSGLPR ; SAMSELHGNM ; YIEVCTACTP ; 250: NREYVRVFDV ; TERTALHRHQ ; TGRTCHKCGG ; QLRDTIVHFG ; ERGTLGQPLN ; 300: WEAATEAASK ; ADTILCLGSS ; LKVLKKYPHL ; WCMTKPPSRR ; PKLYIVNLQW ; 350: TPKDDWAALK ; LHGKCDDVMQ ; LLMDELGLEI ; PRYSRWQDPI ; FSLATPLRAG ; 400:
Sequence Length	400
Sub Unit	Interacts with UBTF and the RNA polymerase I complex. Interacts with components of the B-WICH complex, such as MYBBP1A, SMARCA5/SNF2H and BAZ1B/WSTF. Interacts with ELK4, leading to stabilization at target promoters for H3K18Ac deacetylation. Interacts with histone H2A and/or histone H2B.

Uniprot	Q0P595
Gene Name	SIRT7
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:505662
Unigene	Bt.12071

Reference	1. NIH - Mammalian Gene Collection (MGC) project Submitted (2006-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Hereford. tissue: Ascending colon.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810221	E11385b	96T	$900		Add to Cart

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