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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Membrane cofactor protein

SKU : BHE13812190

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1275b
Alternative Names	CD46 ; MCP
Categories	Elisa
Function	Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). In case of bovine viral diarrhea virus (BVDV) infection, involved in virus attachment to cells.
Specificity	Natural and recombinant Bovine Membrane cofactor protein
Subcellular Location	Cytoplasmic vesicle secretory vesicle acrosome inner membrane Single-pass type I membrane protein Inner acrosomal membrane of spermatozoa.
Detection Range	31.2-2000pg/ml
Entryname	MCP_BOVIN
Method Type	Sandwich
Platform	PF00084
Protein Name	Membrane cofactor protein
Sensitivity	12.3pg/ml
Sequence	50: MRASCTPLKA ; PLRRPERLAS ; SGRFAWVLLL ; APLLLLPTSS ; DACDDPPRFV ; 100: SMKPQGTLKP ; SYSPGEQIVY ; ECHLGFQPVT ; PGQVLALVCQ ; DNNTWSSLQE ; 150: GCKKRRCPTL ; ADPTNGQVIL ; VNGSTEFGSE ; VHYVCNNGYY ; LLGTNISYCE ; 200: VSSGTGVNWS ; DNPPTCEKIL ; CQPPPEIQNG ; KYTNSHKDVF ; EYNEVVTYSC ; 250: DPSNGPDEYS ; LVGESKLTCI ; GNGEWSSQPP ; QCKVVKCVYP ; AIEHGTIVSG ; 300: FGPKYYYKAT ; VVLKCNEGFN ; LYGNSVVVCG ; ENSTWEPELP ; KCIKGHPPRP ; 350: TDASPPNGAE ; GLGAGYIVLV ; IVAVLIGVGL ; LLCLYCCFCR ; QRKKGIYVTG ; 361: ESHRQDILFS ; L
Sequence Length	361
String	Q6VE48
Sub Unit	Interacts with C3b and C4b.

Uniprot	Q6VE48
Gene Name	CD46
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:280851
Unigene	Bt.53657

Reference	1. "Subtractive expression cloning reveals high expression of CD46 at the blood-brain barrier." Shusta E.V., Zhu C., Boado R.J., Pardridge W.M. J. Neuropathol. Exp. Neurol.61:597-604(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY tissue: Brain endothelium. 2. "CD46 is a cellular receptor for bovine viral diarrhea virus." Maurer K., Krey T., Moennig V., Thiel H.-J., Ruemenapf T. J. Virol.78:1792-1799(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);PROTEIN SEQUENCE OF 49-69 AND 237-254;GLYCOSYLATION;TISSUE SPECIFICITY;INTERACTION WITH BOVINE VIRAL DIARRHEA VIRUS tissue: Lymph node.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13812190	E1275b	96T	$900		Add to Cart

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