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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Hypoxia-inducible factor 1-alpha

SKU : BHE13805365

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0798b
Categories	Elisa
Function	Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP.
Specificity	Natural and recombinant Bovine Hypoxia-inducible factor 1-alpha
Subcellular Location	Cytoplasm Nucleus Cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
Entryname	HIF1A_BOVIN
Platform	PF11413
Protein Name	Hypoxia-inducible factor 1-alpha
Sequence	50: MEGAGGANDK ; KKISSERRKE ; KSRDAARSRR ; SKESEVFYEL ; AHQLPLPHNV ; 100: SSHLDKASVM ; RLTISYLRVR ; KLLDAGDLDI ; EDEMKAQMNC ; FYLKALDGFV ; 150: MVLTDDGDMI ; YISDNVNKYM ; GLTQFELTGH ; SVFDFTHPCD ; HEEMREMLTH ; 200: RNGLVKKGKE ; QNTQRSFFLR ; MKCTLTSRGR ; TMNIKSATWK ; VLHCTGHIHV ; 250: YDTNSNQSQC ; GYKKPPMTCL ; VLICEPIPHP ; SNIEIPLDSK ; TFLSRHSLDM ; 300: KFSYCDERIT ; ELMGYEPEEL ; LGRSIYEYYH ; ALDSDHLTKT ; HHDMFTKGQV ; 350: TTGQYRMLAK ; RGGYVWIETQ ; ATVIYNTKNS ; QPQCIVCVNY ; VVSGIIQHDL ; 400: IFSLQQTECV ; LKPVESSDMK ; MTQLFTKVES ; EDTSSLFDKL ; KKEPDALTLL ; 450: APAAGDTIIS ; LDFGSNDTET ; DDQQLEEVPL ; YNDVMLPSSN ; EKLQNINLAM ; 500: SPLPASETPK ; PLRSSADPAL ; NQEVALKLEP ; NPESLELSFT ; MPQIQDQPAS ; 550: PSDGSTRQSS ; PEPNSPSEYC ; FDVDSDMVNE ; FKLELVEKLF ; AEDTEAKNPF ; 600: STQDTDLDLE ; MLAPYIPMDD ; DFQLRSFDQL ; SPLENSSTSP ; QSASTNTVFQ ; 650: PTQMQKPPIA ; TVTTTATSDE ; LKTVTKDGME ; DIKILIAFPS ; PPHVPKEPPC ; 700: ATTSPYSDTG ; SRTASPNRAG ; KGVIEQTEKS ; HPRSPNVLSV ; ALSQRTTAPE ; 750: EELNPKILAL ; QNAQRKRKIE ; HDGSLFQAVG ; IGTLLQQPDD ; RATTTSLSWK ; 800: RVKGCKSSEQ ; NGMEQKTIIL ; IPSDLACRLL ; GQSMDESGLP ; QLTSYDCEVN ; 823: APIQGSRNLL ; QGEELLRALD ; QVN
Sequence Length	823
String	Q9XTA5
Sub Unit	Interacts with COPS5 subunit of COP9 signalosome complex, leading to the regulation of its stability. Efficient DNA binding requires heterodimerization of an alpha and a beta/ARNT subunit. Interacts with NCOA1, NCOA2, APEX, HSP90 and TSGA10. Interacts with VHL which docks HFA1 to the E3 ubiquitin ligase complex for subsequent destruction. Interaction, via the ODD domain, with the beta domain of VHLL, protects HIF1A from destruction by competing against the destructive targeting initiated by VHL. Interacts with RORA (via the DNA binding domain); the interaction enhances HIF1A transcription under hypoxia through increasing protein stability. Interaction with PSMA7 inhibits the transactivation activity of HIF1A under both normoxic and hypoxia-mimicking conditions (By similarity). Interacts with USP20. Interacts with GNB2L1/RACK1; promotes HIF1A ubiquitination and proteasome-mediated degradation. Interacts with EP300 (via TAZ-type 1 domain); the interaction is stimulated in response to hypoxia and inhibited by CITED2. Interacts with CREBBP (via TAZ-type 1 domain).

Uniprot	Q9XTA5
Gene Name	HIF1A
Immunogen Species	Bos Taurus (Cattle)
Unigene	Bt.4184

Reference	1. "Molecular cloning of cDNAs encoding hypoxia-inducible factor (HIF)-1alpha and -2alpha of bovine arterial endothelial cells." Hara S., Kobayashi C., Imura N. Biochim. Biophys. Acta1445:237-243(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Artery.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805365	E0798b	96T	$900		Add to Cart

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