In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Specificity
Natural and recombinant Bovine Hormone-sensitive lipase
Subcellular Location
Cell membrane Membrane caveola Cytoplasm cytosol Found in the high-density caveolae (By similarity). Translocates to the cytoplasm from the caveolae upon insulin stimulation.
"cDNA cloning of bovine LIPE gene." Guo Y.Q., Xu S.Z., Gao X., Zhang L.P. Submitted (2006-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.
"HSL Gene Sequence and Phylogenetic Evolution of Bovinae (Bos taurus, Bos grunniens, Bubalus bubalis, and Bos frontalis)." Ma Z.-J., Zhong J.-C., Guan W.-X., Zhao S., He K. Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-169
"Sequencing of hormone-sensitive lipase (LIPE) gene in Korean cattle." Chung E.R., Shin S.C., Park J.G., Gwon S.Y. Submitted (2006-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-169
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 545-571;PHOSPHORYLATION AT SER-552 AND SER-554
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 552-556;PHOSPHORYLATION AT SER-554