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ELISA Kit for Bovine Heparanase

SKU : BHE13805136

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0711b
Categories	Elisa
Function	Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Highly selective enzyme cleaving HSPGs at specific intrachain sites. Essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans. Acts as procoagulant by enhancing the generation of activated factor X/F10 in the presence of tissue factor/TF and activated factor VII/F7. Independent of its enzymatic activity, increases cell adhesion to the extracellular matrix (ECM). Enhances AKT1/PKB phosphorylation, possibly via interaction with a lipid raft-resident receptor. Plays a role in the regulation of osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
Specificity	Natural and recombinant Bovine Heparanase
Subcellular Location	Lysosome membrane Peripheral membrane protein Secreted Nucleus Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium.
Entryname	HPSE_BOVIN
Platform	PF03662
Protein Name	Heparanase
Sequence	50: MLACRKPGLR ; PPLLLLLPLL ; GPLGPCSPGT ; PAAAAPADDA ; AELEFFTERP ; 100: LHLVSPAFLS ; FTIDANLATD ; PRFFTFLGSS ; KLRTLARGLA ; PAYLRFGGNK ; 150: GDFLIFDPKK ; EPAFEERSYW ; LSQSNQDICK ; SGSIPSDVEE ; KLRLEWPFQE ; 200: QVLLREQYQK ; KFTNSTYSRS ; SVDMLYTFAS ; CSGLNLIFGV ; NALLRTTDMH ; 250: WDSSNAQLLL ; DYCSSKNYNI ; SWELGNEPNS ; FQRKAGIFIN ; GRQLGEDFIE ; 300: FRKLLGKSAF ; KNAKLYGPDI ; GQPRRNTVKM ; LKSFLKAGGE ; VIDSVTWHHY ; 350: YVNGRIATKE ; DFLNPDILDT ; FISSVQKTLR ; IVEKIRPLKK ; VWLGETSSAF ; 400: GGGAPFLSNT ; FAAGFMWLDK ; LGLSARMGIE ; VVMRQVLFGA ; GNYHLVDGNF ; 450: EPLPDYWLSL ; LFKKLVGNKV ; LMASVKGPDR ; SKFRVYLHCT ; NTKHPRYKEG ; 500: DLTLYALNLH ; NVTKHLELPH ; HLFNKQVDKY ; LIKPSGTDGL ; LSKSVQLNGQ ; 545: ILKMVDEQTL ; PALTEKPLHP ; GSSLGMPPFS ; YGFFVIRNAK ; VAACI
Sequence Length	545
String	Q9MYY0
Sub Unit	Heterodimer; heterodimer formation between the 8 kDa and the 50 kDa subunits is required for enzyme activity (By similarity). Interacts with TF; the interaction, inhibited by heparin, enhances the generation of activated factor X and activates coagulation. Interacts with HRG; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts with SDC1; the interaction enhances the shedding of SDC1.

Uniprot	Q9MYY0
Gene Name	HPSE
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:281230
Unigene	Bt.8127

Reference	1. "Expression of heparanase mRNA in bovine placenta during gestation." Kizaki K., Nakano H., Nakano H., Takahashi T., Imai K., Hashizume K. Reproduction121:573-580(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY tissue: Placenta.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805136	E0711b	96T	$900		Add to Cart

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