Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and as well other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions.
Specificity
Natural and recombinant Bovine Fatty acid desaturase 2
Subcellular Location
Endoplasmic reticulum membrane Multi-pass membrane protein