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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine Disintegrin and metalloproteinase domain-containing protein 10

SKU : BHE13800655

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0766b
Alternative Names	Kuzbanian protein homolog ; Mammalian disintegrin-metalloprotease ; Myelin-associated metalloproteinase ; CD156c ; MADM
Categories	Elisa
Function	Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. May regulate the EFNA5-EPHA3 signaling.
Specificity	Natural and recombinant Bovine Disintegrin and metalloproteinase domain-containing protein 10
Subcellular Location	Golgi apparatus membrane Single-pass type I membrane protein Cell membrane Single-pass type I membrane protein The protealytically actived form is localized mainly in the plasma membrane whereas the proenzyme is found intracellularly in the Golgi.
Entryname	ADA10_BOVIN
Platform	PF00200
Protein Name	Disintegrin and metalloproteinase domain-containing protein 10
Sequence	50: MVLLRVLILL ; LSWVAGLGGQ ; YGNPLNKYIR ; HYEGLSYDVD ; SLHQKHQRAK ; 100: RAVSHEDQFL ; RLDFHAHGRH ; FNLRMKRDTS ; LFSEEFRVET ; SNAVLDYDTS ; 150: HIYTGHIYGE ; EGSFSHGSVI ; DGRFEGFIQT ; HGGTFYVEPA ; ERYIKDRTLP ; 200: FHSVIYHEDD ; IKYPHKYGPQ ; GGCADHSVFE ; RMRKYQMTGV ; EEVTQTPQEK ; 250: HAINGPELLR ; KKRTTVAEKN ; TCQLYIQTDH ; LFFKYYGTRE ; AVIAQISSHV ; 300: KAIDTIYQTT ; DFSGIRNISF ; MVKRIRINTT ; ADEKDPTNPF ; RFPNIGVEKF ; 350: LELNSEQNHD ; DYCLAYVFTD ; RDFDDGVLGL ; AWVGAPSGSS ; GGICEKSKLY ; 400: SDGKKKSLNT ; GIITVQNYGS ; HVPPKVSHIT ; FAHEVGHNFG ; SPHDSGTECT ; 450: PGESKNLGQK ; ENGNYIMYAR ; ATSGDKLNNN ; KFSLCSIRNI ; SQVLEKKRNN ; 500: CFVESGQPIC ; GNGMVEQGEE ; CDCGYSDQCK ; DECCYDANQP ; EGKKCKLKPG ; 550: KQCSPSQGPC ; CTAHCAFKSK ; TEKCRDDSDC ; AKEGICNGIT ; ALCPASDPKP ; 600: NFTDCNRHTQ ; VCINGQCAGS ; ICEKHGLEEC ; TCASSDGKDD ; KELCHVCCMK ; 650: KMEPSTCAST ; GSVQWNKYFL ; GRTITLQPGS ; PCNDFRGYCD ; VFMRCRLVDA ; 700: DGPLARLKKA ; IFSPELYENI ; AEWIVAYWWA ; VLLMGIALIM ; LMAGFIKICS ; 748: VHTPSSNPKL ; PPPKPLPGTL ; KRRRPPQPIQ ; QPQRQRPRES ; YQMGHMRR
Sequence Length	748
String	Q10741
Sub Unit	Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with EPHA2.

Uniprot	Q10741
Gene Name	ADAM10
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:282132
Unigene	Bt.49218

Reference	1. "Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types." Howard L., Mitchell S., Lu X., Griffiths S., Glynn P. Biochem. J.317:45-50(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Brain. 2. "Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease." Lammich S., Kojro E., Postina R., Gilbert S., Pfeiffer R., Jasionowski M., Haass C., Fahrenholz F. Proc. Natl. Acad. Sci. U.S.A.96:3922-3927(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 214-233;FUNCTION;MUTAGENESIS OF GLU-384 3. NIH - Mammalian Gene Collection (MGC) project Submitted (2007-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Hereford. tissue: Basal ganglia. 4. "Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans." Janes P.W., Saha N., Barton W.A., Kolev M.V., Wimmer-Kleikamp S.H., Nievergall E., Blobel C.P., Himanen J.P., Lackmann M., Nikolov D.B. Cell123:291-304(2005) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 455-646;DISULFIDE BONDS;SUBUNIT;MUTAGENESIS OF GLU-573; GLU-578 AND GLU-579

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800655	E0766b	96T	$900		Add to Cart

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