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ELISA Kit for Bovine Cartilage oligomeric matrix protein

SKU : BHE13803219

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1197b
Categories	Elisa
Function	May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
Specificity	Natural and recombinant Bovine Cartilage oligomeric matrix protein
Subcellular Location	Secreted extracellular space extracellular matrix
Entryname	COMP_BOVIN
Platform	PF11598
Protein Name	Cartilage oligomeric matrix protein
Sequence	50: MVLAAARVLL ; LTLAALGASG ; QGQMPLGGDL ; GPQMLRELQE ; TNAALQDVRD ; 100: LLRQQVKEIT ; FLKNTVMECD ; ACGMQPARTP ; KLTVRPLSQC ; SPGFCFPGVA ; 150: CTETANGARC ; GPCPEGFTGN ; GSHCADVNEC ; TAHPCFPRVR ; CINTSPGFRC ; 200: EACPPGFSGP ; THEGVGLAFA ; KANKQVCTDI ; NECETGQHNC ; VPNSVCVNTV ; 250: GSFQCGPCQP ; GFVGDQASGC ; RRRPQRFCPD ; GTPSPCHEKA ; DCVLERDGSR ; 300: SCVCAVGWAG ; NGLICGRDTD ; LDGFPDEKLR ; CSERQCRKDN ; CVTVPNSGQE ; 350: DVDQDGIGDA ; CDPDADGDGV ; LNEKDNCPLV ; RNPDQRNTDG ; DKWGDACDNC ; 400: RSQKNDDQKD ; TDKDGRGDAC ; DDDIDGDRIR ; NPVDNCPKVP ; NSDQKDTDGD ; 450: GVGDACDNCP ; QKSNADQRDV ; DHDFVGDACD ; SDQDQDGDGH ; QDSKDNCPTV ; 500: PNSAQQDSDH ; DGQGDACDDD ; DDNDGVPDSR ; DNCRLVPNPG ; QEDMDRDGVG ; 550: DACQGDFDAD ; KVVDKIDVCP ; ENAEVTLTDF ; RAFQTVVLDP ; EGDAQIDPNW ; 600: VVLNQGMEIV ; QTMNSDPGLA ; VGYTAFNGVD ; FEGTFHVNTA ; TDDDYAGFIF ; 650: GYQDSSSFYV ; VMWKQMEQTY ; WQANPFRAVA ; EPGIQLKAVK ; SSTGPGEQLR ; 700: NALWHTGDTA ; SQVRLLWKDP ; RNVGWKDKTS ; YRWFLQHRPQ ; VGYIRVRFYE ; 750: GPELVADSNV ; ILDTTMRGGR ; LGVFCFSQEN ; IIWANLRYRC ; NDTIPEDYEA ; 756: QRLLQA
Sequence Length	756
String	P35445
Sub Unit	Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium. Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca(2+), Mg(2+) or Mn(2+)). The greatest amount of binding is seen in the presence of Mn(2+). Interacts with MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate. Interacts with collagen I, II and IX and interaction with these collagens is dependent on the presence of zinc ions (By similarity). Interacts with MATN1. Interacts with ADAMTS12. Interacts with ITGA7.

Uniprot	P35445
Gene Name	COMP
Immunogen Species	Bos Taurus (Cattle)
Unigene	Bt.3034

Reference	1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution." The bovine genome sequencing and analysis consortium Science324:522-528(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] strain: Hereford. 2. "COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins." Oldberg A., Antonsson P., Lindblom K., Heinegaard D. J. Biol. Chem.267:22346-22350(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-756 tissue: Cartilage. 3. "Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias." Mann H.H., Oezbek S., Engel J., Paulsson M., Wagener R. J. Biol. Chem.279:25294-25298(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MATN1

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803219	E1197b	96T	$900		Add to Cart

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