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ELISA Kit for Bovine C-X-C chemokine receptor type 4

SKU : BHE13803173

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2170b
Alternative Names	Fusin ; LCR1 ; Leukocyte-derived seven transmembrane domain receptor ; LESTR ; Stromal cell-derived factor 1 receptor ; SDF-1 receptor ; CD184
Categories	Elisa
Function	Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
Specificity	Natural and recombinant Bovine C-X-C chemokine receptor type 4
Subcellular Location	Cell membrane Multi-pass membrane protein In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated.
Detection Range	0.156-10ng/mL
Entryname	CXCR4_BOVIN
Method Type	Sandwich
Platform	PF00001
Protein Name	C-X-C chemokine receptor type 4
Sensitivity	0.082ng/mL
Sequence	50: MEGIRIFTSD ; NYTEDDLGSG ; DYDSMKEPCF ; REENAHFNRI ; FLPTVYSIIF ; 100: LTGIVGNGLV ; ILVMGYQKKL ; RSMTDKYRLH ; LSVADLLFVL ; TLPFWAVDAV ; 150: ANWYFGKFLC ; KAVHVIYTVN ; LYSSVLILAF ; ISLDRYLAIV ; HATNSQKPRK ; 200: LLAEKVVYVG ; VWLPAVLLTI ; PDLIFADIKE ; VDERYICDRF ; YPSDLWLVVF ; 250: QFQHIVVGLL ; LPGIVILSCY ; CIIISKLSHS ; KGYQKRKALK ; TTVILILTFF ; 300: ACWLPYYIGI ; SIDSFILLEI ; IQQGCEFEST ; VHKWISITEA ; LAFFHCCLNP ; 350: ILYAFLGAKF ; KTSAQHALTS ; VSRGSSLKIL ; SKGKRGGHSS ; VSTESESSSF ; 353: HSS
Sequence Length	353
String	P25930
Sub Unit	Monomer (By similarity). Can form dimers (By similarity). Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin.

Uniprot	P25930
Gene Name	CXCR4
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:281736
Unigene	Bt.8957

Reference	1. "Sequence and expression of a neuropeptide Y receptor cDNA." Rimland J., Xin W., Sweetnam P., Saijoh K., Nestler E.J., Duman R.S. Mol. Pharmacol.40:869-875(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY tissue: Locus coeruleus. 2. "Role of chemokines in respiratory syncytial virus infection." Werling D. Submitted (2001-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. NIH - Mammalian Gene Collection (MGC) project Submitted (2005-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Hereford. tissue: Thymus. 4. "A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells." Jazin E.E., Yoo H., Blomqvist A.G., Yee F., Weng G., Walker M.W., Salon J., Larhammar D., Wahlestedt C.R. Regul. Pept.47:247-258(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SHOWS THAT IT IS NOT A NPY3R

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803173	E2170b	96T	$900		Add to Cart

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