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Home / Assay Kits / ELISA Kits

ELISA Kit for Bovine 14-3-3 protein zeta/delta

SKU : BHE13800017

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14294b
Alternative Names	Factor activating exoenzyme S ; FAS ; Protein kinase C inhibitor protein 1 ; KCIP-1
Categories	Elisa
Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin.
Specificity	Natural and recombinant Bovine 14-3-3 protein zeta/delta
Subcellular Location	Cytoplasm Melanosome Located to stage I to stage IV melanosomes.
Detection Range	78-5000pg/mL
Entryname	1433Z_BOVIN
Method Type	Sandwich
Platform	PF00244
Protein Name	14-3-3 protein zeta/delta
Sensitivity	40.5pg/mL
Sequence	50: MDKNELVQKA ; KLAEQAERYD ; DMAACMKSVT ; EQGAELSNEE ; RNLLSVAYKN ; 100: VVGARRSSWR ; VVSSIEQKTE ; GAEKKQQMAR ; EYREKIETEL ; RDICNDVLSL ; 150: LEKFLIPNAS ; QAESKVFYLK ; MKGDYYRYLA ; EVAAGDDKKG ; IVDQSQQAYQ ; 200: EAFEISKKEM ; QPTHPIRLGL ; ALNFSVFYYE ; ILNSPEKACS ; LAKTAFDEAI ; 245: AELDTLSEES ; YKDSTLIMQL ; LRDNLTLWTS ; DTQGDEAEAG ; EGGEN
Sequence Length	245
String	P63103
Sub Unit	Homodimer. Heterodimerizes with YWHAE (By similarity). Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58 (By similarity). Interacts with FOXO4, NOXA1, SSH1 ARHGEF2, CDK16 and BSPRY. Interacts with WEE1 (C-terminal). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with TP53; the interaction enhances p53 transcriptional acivity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with AANAT ('Thr-31' phosphorylated form); the interaction modulates AANAT enzymatic activity through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT ('Ser-205' phosphorylated form), can bind the other YWHAZ monomer with similar effect. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization (By similarity). Interacts with GAB2. Interacts with SAMSN1 (By similarity). Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with Thr-phosphorylated ITGB2. Interacts with BCL2L11.

Uniprot	P63103
Gene Name	YWHAZ
Immunogen Species	Bos Taurus (Cattle)
Kegg	bta:287022
Unigene	Bt.88043

Reference	1. "Activation of protein kinase C by the 14-3-3 proteins homologous with Exo1 protein that stimulates calcium-dependent exocytosis." Isobe T., Hiyane Y., Ichimura T., Okuyama T., Takahashi N., Nakajo S., Nakaya K. FEBS Lett.308:121-124(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE tissue: Brain. 2. "The eukaryotic host factor that activates exoenzyme S of Pseudomonas aeruginosa is a member of the 14-3-3 protein family." Fu H., Coburn J., Collier R.J. Proc. Natl. Acad. Sci. U.S.A.90:2320-2324(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 104-115; 140-157 AND 194-212 tissue: Brain. 3. NIH - Mammalian Gene Collection (MGC) project Submitted (2005-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] strain: Crossbred X Angus. tissue: Ileum. 4. "Activation of protein kinase C by purified bovine brain 14-3-3: comparison with tyrosine hydroxylase activation." Tanji M., Horwitz R., Rosenfeld G., Waymire J.C. J. Neurochem.63:1908-1916(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 5. "Crystal structure of the zeta isoform of the 14-3-3 protein." Liu D., Blenkowska J., Petosa C., Collier R.J., Fu H., Liddington R. Nature376:191-194(1995) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) 6. "14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove." Petosa C., Masters S.C., Bankston L.A., Pohl J., Wang B., Fu H., Liddington R.C. J. Biol. Chem.273:16305-16310(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.35 ANGSTROMS) IN COMPLEX WITH PHOSPHORYLATED RAF1;INTERACTION WITH PHOSPHOSERINE PEPTIDE;SUBUNIT 7. "Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding." Takala H., Nurminen E., Nurmi S.M., Aatonen M., Strandin T., Takatalo M., Kiema T., Gahmberg C.G., Ylaenne J., Fagerholm S.C. Blood112:1853-1862(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH PHOSPHORYLATED ITGB2;INTERACTION WITH PHOSPHORYLATED ITGB2

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800017	E14294b	96T	$900		Add to Cart

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