Apicidin

Mfr.No.	SIH-346
Alternative Names	(3S,6S,9S,15aR)-9-[(2S)-2-Butanyl]-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone; Cyclo(N-O-methyl-L-tryptophanyl-L Lisoleucinyl-Dpipecolinyl-L-2-amino-8-oxodecanoyl)
Appearance	White Solid
Function	HDAC inhibitor
Inchi	InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-,26-,27-,29+,30-/m0/s1
Inchikey	JWOGUUIOCYMBPV-GMFLJSBRSA-N
Mode Of Action	Inhibitor
Molecular Formula	C34H49N5O6
Pubchem Cid	6918328
Research Area	Cell Signaling ; Epigenetics and Nuclear Signaling ; Cancer
Safety Phrases	Classification: Toxic. May be harmful or fatal if inhaled, swallowed, or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H300+H310 – Fatal if swallowed or in contact with skin. H330 – Fatal if inhaled Precautionary Statements: P260 – Do not breathe dust/fumes/gas/mist/vapours/spray P264- Wash hands thoroughly after handling P280 – Wear protective gloves/ Protective clothing P284 – Wear respiratory protection P302 + P350 – If on skin: Gently wash with plenty of soap and water. P310 – Immediately call a poison center or doctor/ physician
Smiles	CC[C@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	183506-66-3
Molecular Weight	623.8
Scientific Background	Cyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1α protein levels and transcriptional activity in human and mouse tumor cell lines. Cell permeable.
Solubility	Soluble in 10 mg/ml DMSO or 100% Ethanol
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.001
Purity	>98% (HPLC); NMR (conforms)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Darkin-Rattray S.J., et al. (1996) Proc. Natl. Acad. Sci. USA. 93: 13143. 2. Han J.W., et al. (2000) Cancer Res. 60: 6068. 3. Kim S.H., et al. (2007) Oncol. Rep. 17: 647.

Have you used this product?

Rate it now..!!

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900134-1	SIH-346-1MG	1 mg	$72		Add to Cart
BHB11900134-2	SIH-346-5MG	5 mg	$276		Add to Cart

Contact us to order

Tel

Email

Contact us to order

Tel

Email

Reviews of Apicidin

Rate it now..!!