Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9(Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
Host
Rabbit
Immunogen
apoptotic peptidase activating factor 1
Isotype
IgG
Molecular Weight
140 kDa
Reactivity
Human, Rat, Mouse
Regulatory
RUO
Synonyms
APAF 1, APAF1, CED4, KIAA0413
Uniprot
O14727
Gene Id
317
Research Area
Developmental biology
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)