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Home / Primary Antibodies / Polyclonal Antibodies

XRCC5/Ku80 antibody

SKU : BHA10809526

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Mfr.No.	FNab09555
Alternative Names	86kDasubunitofKuantigen ; CTC85 ; CTCBF ; DNArepairproteinXRCC5 ; FLJ39089 ; G22P2 ; KARP1 ; KARP1 ; Ku80 ; Ku86 ; KUB2
Background	The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Categories	Primary Antibodies
Cellular Localization	Chromosome, Nucleus
Clonality	polyclonal
Description	There are at least two pathways for eukaryotes to repair DNA double-strand breaks: homologous recombination and nonhomologous end joining(NHEJ). The core NHEJ machinery includes XRCC4, DNA ligase IV and the DNA-dependent protein kinase complex, which consists of the DNA end-binding XRCC5/XRCC6 heterodimer and the catalytic subunit PRKDC. The heterdimer of XRCC5/XRCC6 enhanced teh affinity of the catalytic subunit PRKDC to DNA by 100-fold. Once the XRCC5/6 dimer association with NAA15, it can bind to the osteocalcin promoter and activate osteocalcin expression. The XRCC5/6 dimer acts as a negative regulator of transcription when together with APEX1. Some publised papers indicated that the MW of XRCC5 is 86kDa, while more papers suggested that XRCC5 is a 80kDa protein, as it was firstly introducted in publication. Thus, Ku80 and Ku86 are the same protein.
Host	Rabbit
Immunogen	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Isotype	IgG
Molecular Weight	Refer to figures
Reactivity	Human
Regulatory	RUO
Subcellular Location	Chromosome, Nucleus
Synonyms	86 kDa subunit of Ku antigen, CTC85, CTCBF, DNA repair protein XRCC5, FLJ39089, G22P2, KARP 1, KARP1, Ku80, Ku86, KUB2, NFIV, Nuclear factor IV, Thyroid lupus autoantigen, TLAA, XRCC5

Uniprot	P13010
Gene Id	7520
Research Area	Epigenetics, Metabolism
Weight	83kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF, IP

Description

ELISA ; WB ; IHC ; IF ; IP

Dilution

WB	1:500-1:5000
IHC	1:20-1:200
IF	1:20-1:200
IP	1:500-1:5000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab09555.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809526	FNab09555	100ug	$280		Add to Cart

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