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Home / Primary Antibodies / Polyclonal Antibodies

WRN antibody

SKU : BHA10809497

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Mfr.No.	FNab09524
Alternative Names	DKFZp686C2056 ; DNAhelicase ; RecQliketype3 ; ExonucleaseWRN ; RecQproteinlike2 ; RECQ3 ; RECQL2 ; RECQL3 ; WRN
Background	Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A(By similarity). Plays a role in double-strand break repair after gamma-irradiation.
Categories	Primary Antibodies
Cellular Localization	Nucleus
Clonality	polyclonal
Description	Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.
Host	Rabbit
Immunogen	Werner syndrome, RecQ helicase-like
Isotype	IgG
Molecular Weight	162-200 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Subcellular Location	Nucleus
Synonyms	DKFZp686C2056, DNA helicase, RecQ like type 3, Exonuclease WRN, RecQ protein like 2, RECQ3, RECQL2, RECQL3, WRN

Uniprot	Q14191
Gene Id	7486
Research Area	Epigenetics, Developmental biology, Metabolism
Weight	162kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:200-1:1000

Tested Application

WB: 1:200-1:1000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809497	FNab09524	100ug	$280		Add to Cart

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