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Home / Primary Antibodies / Polyclonal Antibodies

Vimentin antibody

SKU : BHA10809384

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Mfr.No.	FNab09408
Alternative Names	FLJ36605 ; VIM ; Vimentin
Background	This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Intermediate Filament
Clonality	polyclonal
Description	Vimentin, also named as VIM, belongs to the intermediate filament family. Vimentin is class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is important for stabilizing the architecture of the cytoplasm. Monocyte-derived macrophages secrete vimentin into the extracellular space in vitro. Secretion of vimentin was enhanced by the proinflammatory cytokine tumor necrosis factor-alpha (TNFA; 191160) and inhibited by the antiinflammatory cytokine IL10 (124092), suggesting that vimentin is involved in the immune response. Vimentin has specialized functions that contribute to specific dynamic cellular processes. As a phosphoprotein, 55-60 kDa of vimentin proteins can be observed due to the different phosphorylation level.
Host	Rabbit
Immunogen	vimentin
Isotype	IgG
Molecular Weight	55 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Cytoplasm, Intermediate filament
Synonyms	FLJ36605, VIM, Vimentin

Uniprot	P08670
Gene Id	7431
Research Area	Developmental biology, Immunology, Cancer, Stem Cells, Neuroscience
Weight	55kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IF, IHC, WB, FC

Description

ELISA ; IF ; IHC ; WB ; FC

Dilution

WB	1:1000-1:10000
IHC	1:20-1:500
IF	1:50-1:500

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab09408.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809384	FNab09408	100ug	$260		Add to Cart

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