Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
Categories
Primary Antibodies
Cellular Localization
Cytoplasm, Nucleus, Proteasome
Clonality
polyclonal
Description
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
Host
Rabbit
Immunogen
ubiquitin carboxyl-terminal hydrolase L5
Isotype
IgG
Molecular Weight
37 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cytoplasm, Nucleus, Proteasome
Synonyms
CGI 70, INO80R, Ubiquitin thioesterase L5, UCH L5, UCH37, UCHL5
Uniprot
Q9Y5K5
Gene Id
51377
Research Area
Epigenetics, Metabolism
Weight
37kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)