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Home / Primary Antibodies / Polyclonal Antibodies

UBE2B antibody

SKU : BHA10809156

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Mfr.No.	FNab09164
Alternative Names	E217kDa ; HHR6B ; HR6B ; RAD6homologB ; RAD6B ; UBC2 ; UBE2B ; UbiquitincarrierproteinB ; UbiquitinproteinligaseB
Background	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
Categories	Primary Antibodies
Cellular Localization	Membrane, Nucleus
Clonality	polyclonal
Description	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys- 164'. May be involved in neurite outgrowth.
Host	Rabbit
Immunogen	ubiquitin-conjugating enzyme E2B (RAD6 homolog)
Isotype	IgG
Molecular Weight	16 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cell membrane, Membrane, Nucleus
Synonyms	E2 17kDa, HHR6B, HR6B, RAD6 homolog B, RAD6B, UBC2, UBE2B, Ubiquitin carrier protein B, Ubiquitin protein ligase B

Uniprot	P63146
Gene Id	7320
Research Area	Epigenetics, Cell Division and Proliferation, Developmental biology, Metabolism
Weight	17kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB

Description

ELISA ; IHC ; WB

Dilution

WB	1:200-1:2000
IHC	1:10-1:100

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab09164.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809156	FNab09164	100ug	$260		Add to Cart

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