Tuberous sclerosis 2, also known as TSC2 or Tuberin is a protein that is in humans. Mutations in this gene lead to tuberous sclerosis complex. TSC2 is believed to be a tumor suppressor and is able to stimulate specific GTPases. It associates with hamartin in a cytosolic complex, possibly acting as a chaperone for<a href=../search_result.php?search_txt=hamartin>Hamartin</a>. TSC2 is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. It stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and<a href=../search_result.php?search_txt=rab5a>RAB5</a>in vitro.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Human partial recombinant protein (AA 1611-1807) was used as the immunogen for this TSC2 antibody.
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Gene Id
7249
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
The lyophilized TSC2 antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freeze/thaws.
Applications
WB, IHC-P
Dilution
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml