Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine(PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules(By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification(PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay(By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating(By similarity).
Categories
Primary Antibodies
Cellular Localization
Membrane
Clonality
polyclonal
Description
Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
Host
Rabbit
Immunogen
transient receptor potential cation channel, subfamily V, member 5
Isotype
IgG
Molecular Weight
43 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Apical cell membrane
Synonyms
Calcium transport protein 2, CAT2, ECaC, ECAC1, Epithelial calcium channel 1, Osm 9 like TRP channel 3, OTRPC3, TRPV5
Uniprot
Q9NQA5
Gene Id
56302
Research Area
Epigenetics, Metabolism
Weight
43kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)