Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Categories
Primary Antibodies
Cellular Localization
Embrane, Membrane
Clonality
polyclonal
Description
Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Host
Rabbit
Immunogen
transient receptor potential cation channel, subfamily C, member 4
Isotype
IgG
Molecular Weight
112 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cell membrane,membrane
Synonyms
HTrp 4, HTRP4, Trp related protein 4, TRP4, TRPC4
Uniprot
Q9UBN4
Gene Id
7223
Research Area
Signal Transduction, Neuroscience
Weight
112kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)