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Home / Primary Antibodies / Polyclonal Antibodies

TREX1 antibody

SKU : BHA10808955

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Mfr.No.	FNab08963
Alternative Names	35exonucleaseTREX1 ; AGS1 ; AGS5 ; CRV ; DKFZp434J0310 ; DNaseIII ; DRN3 ; HERNS ; TREX1
Background	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA(ssDNA) and double-stranded DNA(dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA(ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Host	Rabbit
Immunogen	three prime repair exonuclease 1
Isotype	IgG
Molecular Weight	32 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	3 5 exonuclease TREX1, AGS1, AGS5, CRV, DKFZp434J0310, DNase III, DRN3, HERNS, TREX1

Uniprot	Q9NSU2
Gene Id	11277
Research Area	Metabolism
Weight	32kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IP

Description

ELISA ; WB ; IP

Dilution

WB	1:200-1:1000
IP	1:200-1:1000

Tested Application

WB: 1:200-1:1000; IP: 1:200-1:1000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808955	FNab08963	100ug	$280		Add to Cart

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