Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
Clonality
polyclonal
Host
Rabbit
Immunogen
TNF receptor-associated factor 5
Immunogen Region
TNF receptor-associated factor 5
Isotype
IgG
Molecular Weight
52-70 kDa
Reactivity
Human, Rat, Mouse
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:50-1:500
Synonyms
RING finger protein 84, RNF84, TRAF5
Uniprot
O00463
Gene Id
7189
Research Area
Signal Transduction
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:50-1:500
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10075.pdf" target="_blank">Data Sheet</ a>