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Home / Primary Antibodies / Polyclonal Antibodies

TOP1 antibody

SKU : BHA10808857

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Mfr.No.	FNab08865
Background	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.
Host	Rabbit
Immunogen	topoisomerase (DNA) I
Isotype	IgG
Molecular Weight	100 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	DNA topoisomerase 1, DNA topoisomerase I, TOP1, TOPI, Top-I, topoisomerase (DNA) I

Uniprot	P11387
Gene Id	7150
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP
Description	ELISA ; WB ; IHC ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IP: 1:50 - 1:100

Manual	FNab08865.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808857	FNab08865	100ug	$260		Add to Cart

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