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Home / Primary Antibodies / Polyclonal Antibodies

TET2 antibody

SKU : BHA10808595

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Mfr.No.	FNab08603
Alternative Names	KIAA1546
Background	The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Host	Rabbit
Immunogen	tet oncogene family member 2
Isotype	IgG
Molecular Weight	224 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	KIAA1546

Uniprot	Q6N021
Gene Id	54790
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IP, WB
Description	ELISA ; IP ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab08603.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808595	FNab08603	100ug	$260		Add to Cart

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