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Home / Primary Antibodies / Polyclonal Antibodies

TERF2IP antibody

SKU : BHA10808591

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Mfr.No.	FNab08599
Alternative Names	DRIP5 ; RAP1
Background	The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
Host	Rabbit
Immunogen	telomeric repeat binding factor 2, interacting protein
Isotype	IgG
Molecular Weight	55 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	DRIP5, RAP1

Uniprot	Q9NYB0
Gene Id	54386
Research Area	Epigenetics, Developmental biology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IHC, IP, FC
Description	ELISA ; WB ; IF ; IHC ; IP ; FC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab08599.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808591	FNab08599	100ug	$260		Add to Cart

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