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Home / Primary Antibodies / Polyclonal Antibodies

TDP1 antibody

SKU : BHA10808564

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Mfr.No.	FNab08572
Background	DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Categories	Primary Antibodies
Clonality	polyclonal
Description	DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Host	Rabbit
Immunogen	tyrosyl-DNA phosphodiesterase 1
Isotype	IgG
Molecular Weight	68 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	Q9NUW8
Gene Id	55775
Research Area	Metabolism, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:500-1:2000; IP: 1:200-1:2000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808564	FNab08572	100ug	$260		Add to Cart

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