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Home / Primary Antibodies / Monoclonal Antibodies

SUR1 Antibody, Clone S289-16 - SMC-409

BHA11903678
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+1 866.986.9598
Email
[email protected]
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Swissprot Q09429
Accession Number NP_037171.2
Gene Id 25559
Target SUR1
Clone No S289-16
Research Area cardiovascular System, Cell Markers, Neuron Markers, Membrane Markers, Cell Signaling, Cancer, Atherosclerosis, Heart, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~160kDa. Does not cross-react with SUR2B.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, WB, ICC/IF
Description WB ; IHC ; ICC ; IF
Dilution WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Campbell J.D., Sansom M.S., Ashcroft F.M. (2003) EMBO Resp. 4(11): 1038-1042.

2. Nichols C.G. (2006) Nature. 440 (7083): 470-476.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11903678-1 SMC-409D Unconjugated 100 ug $330
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BHA11903678-2 SMC-409D-A390 ATTO 390 100 ug $384
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BHA11903678-3 SMC-409D-A488 ATTO 488 100 ug $383
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BHA11903678-4 SMC-409D-A594 ATTO 594 100 ug $383
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BHA11903678-5 SMC-409D-ALP Alkaline Phosphatase 100 ug $376
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BHA11903678-6 SMC-409D-APC APC 100 ug $382
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BHA11903678-7 SMC-409D-BI Biotin 100 ug $378
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BHA11903678-8 SMC-409D-FITC FITC 100 ug $374
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BHA11903678-9 SMC-409D-HRP HRP 100 ug $370
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BHA11903678-10 SMC-409D-PCP PerCP 100 ug $382
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BHA11903678-11 SMC-409D-RPE RPE 100 ug $380
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BHA11903678-12 SMC-409S Unconjugated 12 ug $44
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